Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer
S. Choi, M. A. Whitman, A. A. Shimpi, N. D. Sempertegui, A. Chiou, J. E. Druso, A. Verma, S. C. Lux, Z. Cheng, M. Paszek, O. Elemento, L. A. Estroff, C. Fischbach
The paper shows that mineralization in bone matrix models inhibits tumor cell proliferation and induces a stem-like phenotype, contradicting the assumption that rigidity promotes metastasis.
bioRxiv · Jun 29, 2022 · PreprintBioengineering