M. Paszek

Biocompatibility of KAPs-Depleted Residual Hair

This paper investigates the biocompatibility of residual human hair with varying keratin-associated protein (KAP) levels, finding that lower KAP levels reduce foreign body response in vivo.

The microenvironment dictates glycocalyx construction and immune surveillance

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

The Lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

This study shows that the Lamin A/C Ig-fold undergoes cell density-dependent conformational changes that affect antibody binding, without altering protein levels or nuclear mechanics.

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

The paper shows that mineralization in bone matrix models inhibits tumor cell proliferation and induces a stem-like phenotype, contradicting the assumption that rigidity promotes metastasis.

Nuclear deformation causes DNA damage by increasing replication stress

The paper shows that nuclear deformation during migration or compression causes DNA damage by increasing replication stress, primarily in S/G2 phase, independent of nuclear envelope rupture.