A. Chong

Establishing the foundations for a data-centric AI approach for virtual drug screening through a systematic assessment of the properties of chemical data

This paper demonstrates that conventional ML can achieve high accuracy in virtual screening with proper data and representation, outperforming deep learning methods.

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

This paper describes a novel triptolide analog, CK21, which downregulates the NF-κB pathway and induces mitochondrial apoptosis in human pancreatic cancer cells.

Microtubule-Connexin-43 regulation suppresses arrhythmias and fibrosis in Duchenne muscular dystrophy mice.

This study shows that Cx43 phosphorylation status affects microtubule organization in DMD mice, influencing arrhythmias and fibrosis.

Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing Analyses

This study identifies transcriptomic changes in cardiac fibroblasts associated with cardiac microthrombi in fatal COVID-19 through single nuclei RNA sequencing and clinical analyses.

A scalable, multi-wavelength, broad bandwidth frequency-domain near-infrared spectroscopy platform for real-time quantitative tissue optical imaging

The paper introduces a scalable FD-NIRS platform for real-time tissue optical imaging with high-speed data processing and multi-wavelength capabilities.

O-GlcNAcylation reduces phase separation and aggregation of the EWS N-terminal low complexity region