I. Pritisanac

The paper introduces MIADE guidelines to standardize metadata for experiments studying intrinsically disordered proteins, improving data interpretation and reproducibility.

This paper shows AlphaFold2 can predict structures of conditionally folded intrinsically disordered regions with high precision, revealing their prevalence in human and prokaryotic proteins and their association with disease mutations.

The paper identifies molecular features in intrinsically disordered protein regions that predict functional roles and validates their importance in mitochondrial targeting.

This study investigates how the P182L mutation in HSP27's IxI/V motif disrupts protein interactions, leading to aggregation and disease.

MethylFLYA automatically assigns methyl groups in large proteins using NOESY data, achieving high accuracy and efficiency compared to manual methods.

This study shows that redox-induced monomerization of HSP27 enhances its chaperone activity but also increases aggregation risk, with mutations in an unstructured region linked to neuropathies.