Author
B. Qiu
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2019-2023 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 8 mutual co-author links10 papers
Recent·Most cited
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention
B. Qiu, A. Lawan, C. E. Xirouchaki, J.-S. Yi, M. Robert, L. Zhang, W. Brown, C. Fernandez-Hernando, X. Yang, A. M. Bennett
This study shows MKP1 suppresses AMPK activity via LKB1 nuclear retention, promoting NASH by inducing hepatocyte death and inflammation.
bioRxiv · Jul 10, 2023Physiology
High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET
X. Meng, C. Xu, J. Li, B. Qiu, J. Luo, Q. Hong, Y. Tong, C. Fang, Y. Feng, R. Ma, X. Shi, C. Lin, C. Pan, X. Zhu, X. Yan, Y. Cong
The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.
bioRxiv · Jun 2, 2023 · PreprintBiophysics
A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer
Q. Tian, P. Zhang, Y. Wang, Y. Si, D. Yin, C. R. Weber, M. Fishel, K. E. Pollok, B. Qiu, F. Xiao, A. Chong
This paper describes a novel triptolide analog, CK21, which downregulates the NF-κB pathway and induces mitochondrial apoptosis in human pancreatic cancer cells.
bioRxiv · Feb 15, 2023Pharmacology & Toxicology
Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection
C. M. Spruit, I. R. Sweet, T. Bestebroer, P. Lexmond, B. Qiu, M. J. Damen, R. A. Fouchier, J. Snijder, S. Herfst, G.-J. Boons, R. P. de Vries
This study shows that recent H3N2 influenza A viruses require a low threshold of glycan receptors for efficient infection, and increasing receptor numbers beyond this threshold does not improve infection efficiency.
bioRxiv · Nov 16, 2022Microbiology
An environmentally ultrasensitive fluorine probe to resolve protein conformational ensembles by 19F NMR and cryo-EM
Y. Huang, K. D. Reddy, C. Bracken, B. Qiu, W. Zhan, D. Eliezer, O. Boudker
This paper introduces a fluorine probe that enhances 19F NMR sensitivity for studying protein conformational changes, validated by cryo-EM structural analysis.
bioRxiv · Mar 29, 2022 · PreprintBiophysics
Transport mechanism of the neuronal excitatory amino acid transporter
B. Qiu, D. Matthies, E. Fortea, Z. Yu, O. Boudker
The paper reports Cryo-EM structures of hEAAT3 in different functional states, revealing an elevator mechanism for glutamate transport and conserved sodium-substrate coupling.
bioRxiv · Jun 1, 2020 · PreprintBiophysics
Development of a Murine Model of Pyogenic Flexor Tenosynovitis
B. Qiu, J. Cobb, A. E. Loiselle, C. Ketonis
This paper develops a murine model of pyogenic flexor tenosynovitis using Staphylococcus aureus infection and evaluates its progression through bioluminescence and histopathology.
bioRxiv · Feb 7, 2020Pathology
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
M. Bhattacharyya, Y. K. Lee, S. Muratcioglu, B. Qiu, P. Nyayapati, H. Schulman, J. T. Groves, J. Kuriyan
This study shows that differences in kinase-hub linker lengths between CaMKII and CaMKII-β isoforms affect their autophosphorylation balance, with CaMKII favoring activation and CaMKII-β favoring inhibition.
bioRxiv · Nov 20, 2019Biophysics