ImmunologybioRxiv
Spontaneous human CD8 T cell and EAE-inducible human CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis PBMC humanized mice
I. Papazian, M. Kourouvani, A. Dagkonaki…·L. Probert
This study develops a humanized mouse model of multiple sclerosis using PBMCs from HLA-DRB1*15-positive patients, showing spontaneous and EAE-induced T cell lesions in CNS tissues.
DOI 10.7554/elife.88826.3