Author

A. Davtyan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1

Frequent Co-Authors

A. C. Schramm· 1 shared A. E. P. Durumeric· 1 shared A. Klindziuk· 1 shared A. Kolomeisky· 1 shared A. Meller· 1 shared A. Saeedi· 1 shared D. S. Yang· 1 shared E. M. De La Cruz· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

A. C. Schramm

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Author profile →

3 papers

Recent·Most cited

Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors

A. Meller, S. H. de Oliviera, T. Abramyan, A. Davtyan, G. R. Bowman, H. van den Bedem

The paper shows that using dynamic simulations with an AlphaFold structure improves the prediction of allosteric inhibitor binding to PPM1D compared to static structures.

bioRxiv · Mar 22, 2023 · PreprintBiophysics

Mesoscopic Liquid Clusters Represent a Distinct Condensate of Mutant p53

P. G. Vekilov, D. S. Yang, A. Saeedi, A. Davtyan, M. Fathi, M. Safari, A. Klindziuk, S. Barton, N. Varadarajan, A. Kolomeisky

This study investigates the phase behavior of mutant p53, showing it forms mesoscopic liquid clusters that facilitate amyloid fibril nucleation and revealing that structural destabilization drives condensation.

bioRxiv · Feb 4, 2020 · PreprintBiophysics

Insights into the cooperative nature of ATP hydrolysis in actin filaments

H. H. Katkar, A. Davtyan, A. E. P. Durumeric, G. M. Hocky, A. C. Schramm, E. M. De La Cruz, G. A. Voth

This paper develops a multiscale UCG model to study ATP hydrolysis and Pi release in actin filaments, showing cooperativity affects filament dynamics near critical monomer concentrations.

bioRxiv · May 10, 2018Biophysics