N. Varadarajan

This paper introduces a video diffusion model for early apoptosis prediction by considering cell-cell interactions and spatial-temporal dynamics, achieving high accuracy and low error rates.

This study shows that CAR-T cells engineered to secrete MMP-8 enhance tumor infiltration and anti-tumor activity in solid tumors.

This study profiles the metabolic interactions between TILs and autologous tumor cells in ACT, finding that responder TILs are more efficient at fatty acid oxidation under starvation.

This study demonstrates that fusing proteins to NPC2 enables non-cytotoxic protein delivery by T cells through the perforin pathway.

The paper identifies a four-gene signature associated with EV secretion in breast cancer and links it to poor prognosis and immune evasion.

This paper develops an intranasal multi-antigen vaccine that prevents SARS-CoV-2 infection and transmission by targeting both spike and nucleocapsid proteins.

The paper identifies migration as a cell-intrinsic biomarker for CAR+ T cell efficacy in B-cell malignancies using multi-dimensional single-cell profiling.

This study develops NanoSTING, an intranasal nanoparticle STING agonist, showing broad protection against respiratory viruses and variants in animal models.

This study identifies CD2-CD58 interactions as critical for CAR T cell persistence and antitumor responses in lymphoma patients.

This study uses time-lapse imaging and machine learning to show that SARS-CoV-2-specific cytotoxic T cells can kill multiple infected targets, highlighting their potential for broad immunity.

The paper develops a single-cell technique to profile exosome secretion in breast cancer cells and finds that non-metastatic cells secrete more exosomes, which correlates with better prognosis and immune infiltration.

This study develops an intranasal vaccine that induces systemic and mucosal immunity against SARS-CoV-2 in mice, with single-cell RNA-sequencing confirming T and B cell responses in nasal-associated lymphoid tissues.

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

This study investigates the phase behavior of mutant p53, showing it forms mesoscopic liquid clusters that facilitate amyloid fibril nucleation and revealing that structural destabilization drives condensation.

This study identifies novel roles of autoreactive B cells in RA through transcriptome profiling, revealing potential therapeutic targets and mechanisms.