A. Saeedi

Engineering non-cytotoxic delivery of proteins by T cells via fusion to NPC2

This study demonstrates that fusing proteins to NPC2 enables non-cytotoxic protein delivery by T cells through the perforin pathway.

Ending transmission of SARS-CoV-2: sterilizing immunity using an intranasal subunit vaccine

This paper develops an intranasal multi-antigen vaccine that prevents SARS-CoV-2 infection and transmission by targeting both spike and nucleocapsid proteins.

T-cell potential for CD19-expressing malignancies revealed by multi-dimensional single-cell profiling

The paper identifies migration as a cell-intrinsic biomarker for CAR+ T cell efficacy in B-cell malignancies using multi-dimensional single-cell profiling.

An intranasal nanoparticle STING agonist has broad protective immunity against respiratory viruses and variants

This study develops NanoSTING, an intranasal nanoparticle STING agonist, showing broad protection against respiratory viruses and variants in animal models.

Mesoscopic Liquid Clusters Represent a Distinct Condensate of Mutant p53

This study investigates the phase behavior of mutant p53, showing it forms mesoscopic liquid clusters that facilitate amyloid fibril nucleation and revealing that structural destabilization drives condensation.