Chronic Exposure to Palmitic Acid Downregulates AKT in Beta-Cells through Activation of mTOR
R. Aggarwal, Z. Peng, N. Zeng, J. Silva, L. He, J. Chen, A. Debebe, E. Stiles, C.-Y. Chen, B. L. Stiles
This study shows chronic palmitic acid exposure reduces AKT in beta-cells via mTOR activation, leading to cell cycle inhibition and T2D risk.
bioRxiv · Aug 11, 2020 · PreprintCell Biology