J. Silva

Loss of the Ap4A hydrolase YqeK impairs stress adaptation and virulence gene expression in Staphylococcus aureus

This paper shows that loss of YqeK in S. aureus increases stress sensitivity and reduces virulence gene expression, suggesting YqeK as a target for anti-virulence drugs.

Durable Antimicrobial Microstructure Surface (DAMS) Enabled by 3D-Printing and ZnO Nanoflowers

This study develops a durable antimicrobial surface (DAMS) using 3D-printed microstructures and ZnO nanoflowers, showing over 90% bacterial reduction after 12 hours and effectiveness after abrasion.

Transcriptomic landscape of seedstick in Arabidopsis thaliana funiculus after fertilisation

This study performs transcriptomic analysis of Arabidopsis thaliana funiculus in stk mutants to identify deregulated genes and processes involved in seed development.

Mechanical Resistance to Micro-Heart Tissue Contractility unveils early Structural and Functional Pathology in iPSC Models of Hypertrophic Cardiomyopathy

This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.

An "alert state" ribosome population acts as a master regulator of cytokine mediated processes

The paper identifies an 'alert-state' ribosome subpopulation (ASRs) that regulates cytokine-mediated processes by preferentially translating key mRNAs involved in immune responses.

Validation of the in-house designed one-trial inhibitory avoidance test for two strains of adult zebrafish

The paper validates an open-source one-trial inhibitory avoidance test for two zebrafish strains, showing it effectively measures memory with a robust and long-lasting response.

Visualization of translation reorganization upon persistent collision stress in mammalian cells

The paper visualizes how translation reorganizes in mammalian cells under persistent collision stress, revealing changes in ribosome complexes and quality control mechanisms.

A Non-Canonical IRAK Signaling Pathway Triggered by DNA Damage

The paper identifies a non-canonical IRAK signaling pathway triggered by DNA damage that promotes anti-apoptosis and is activated by ionizing radiation and genotoxic therapies.

FHF2 phosphorylation and regulation of native myocardial NaV1.5 channels

This study identifies phosphorylation sites on FHF2 in mouse NaV1.5 channels and shows differential regulation of neonatal and adult ventricular NaV1.5 by FHF2 phosphorylation.

3D printed magneto-active microfiber scaffolds for remote stimulation of 3D in vitro skeletal muscle models

This paper develops 3D printed magneto-active microfiber scaffolds that can be remotely stimulated to deform, supporting dynamic in vitro skeletal muscle culture without affecting cell viability or differentiation.

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

Exploring Taxonomic and Functional Microbiome of Hawaiian Stream and Spring Irrigation Water Systems Using Illumina and Oxford Nanopore Sequencing Platforms

This study analyzes bacterial communities and their functions in irrigation water from Hawaiian farms using Illumina and Oxford Nanopore sequencing, identifying key taxa and antibiotic resistance genes.

SETD2 negatively regulates cell size through its catalytic activity and SRI domain

This study identifies SETD2 as a negative regulator of cell size through its catalytic activity, independent of H3K36 methylation, and shows that its SRI domain interacts with non-histone substrates to modulate protein synthesis.

A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue

This paper develops a method to isolate endothelial nuclei and RNA from archived frozen brain tissues, showing it reliably extracts endothelial RNA and correlates with whole-cell expression.

The miR-424/503 cluster modulates Wnt/β-catenin signaling in the mammary epithelium by regulating the expression of the LRP6 co-receptor

The paper identifies the miR-424/503 cluster as a regulator of Wnt/β-catenin signaling in mammary epithelium by targeting LRP6, and links its loss to breast cancers with high Wnt/β-catenin activity.

Identification of Structures for Ion Channel Kinetic Models

The paper presents a method to identify Markov model topologies for ion channel dynamics using experimental data from two types of voltage-gated ion channels.

miR-424(322) is a molecular switch controlling pro-inflammatory vs anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling

This study identifies miR-424(322) as a molecular switch that controls the differentiation of pro-inflammatory monocyte-derived DCs (moDCs) versus anti-inflammatory Langerhans cells (LCs) by modulating TGF-β signaling.

Chronic Exposure to Palmitic Acid Downregulates AKT in Beta-Cells through Activation of mTOR

This study shows chronic palmitic acid exposure reduces AKT in beta-cells via mTOR activation, leading to cell cycle inhibition and T2D risk.

Optimizing athlete assessment of maximal force and rate of development A comparison of the isometric squat and mid-thigh pull

This study compares force-time characteristics and muscle activity between isometric squat and mid-thigh pull tests in bilateral and unilateral stances, finding differences in peak force and rate of force development.

Glucocorticoids regulate cancer cell dormancy

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.