Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastoma
A. Vaccaro, F. Yang, T. van de Walle, S. Franke, R. Lugano, A. Denes, A. Magoulopoulou, I. Cid-Farina, A. Smits, L. Uhrbom, S. Libard, F. Latini, M. Essand, M. Nilsson, L. He, , A. Dimberg
This study identifies cellular and molecular mechanisms of tertiary lymphoid structure (TLS) formation in glioblastoma, showing TLS correlate with improved survival and are driven by CD4 T cells expressing lymphotoxin β.
bioRxiv · Jul 4, 2024 · PreprintCancer Biology