M. Nilsson

Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastoma

This study identifies cellular and molecular mechanisms of tertiary lymphoid structure (TLS) formation in glioblastoma, showing TLS correlate with improved survival and are driven by CD4 T cells expressing lymphotoxin β.

Pooled optical screening in bacteria using chromosomally expressed barcodes

The paper develops a method for in situ genotyping of bacterial libraries using chromosomally expressed barcodes to measure intracellular maturation times of red fluorescent proteins.

Single cell-resolution in situ sequencing elucidates spatial dynamics of multiple sclerosis lesion and disease evolution

This study uses single-cell spatial sequencing to analyze MS lesion dynamics in mice and humans, revealing centrifugal lesion propagation and dynamic disease-associated glia.

Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse

The paper identifies predictive biomarkers for relapse in stage II colon cancer using spatial gene expression analysis and introduces the GTC-tool for compartment classification.

Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastoma

This paper harmonizes 26 single-cell RNA sequencing datasets from 240 glioblastoma patients to create GBmap, revealing tumor architecture, intercellular crosstalk, and pro-angiogenic signaling sources.

Spatial genomics maps the structure, character and evolution of cancer clones

The paper develops a spatial genomics method to map cancer clone structure, character, and evolution across breast cancer progression stages.

Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

Direct Electrical Detection of sub-aM DNA Concentrations

This paper introduces a microporous membrane sensor capable of detecting DNA at sub-aM concentrations through optimized mass transport and electrical resistance measurement.

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

The paper uses in situ sequencing to analyze immune transcript localization in tuberculosis granulomas, revealing time-dependent immune landscape changes and spatial transcriptomic patterns.