C. David

A cellular assay to determine the fusion capacity of MFN2 variants linked to Charcot-Marie-Tooth type 2A

This paper develops a cellular assay to assess MFN2 variants' fusion capacity in CMT2A and shows correlation with computational predictions.

Infection-induced vascular inflammation in COVID-19 links focal microglial dysfunction with neuropathologies through IL-1/IL-6-related systemic inflammatory states

Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival

This study shows mammalian cells internalize bacteriophage T4, which enhances cellular growth and survival through AKT-dependent pathways and G1 phase prolongation without triggering inflammatory responses.

Metamorphic proteins at the basis of human autophagy initiation and lipid transfer

This study identifies the molecular mechanism of autophagy initiation by revealing the role of metamorphic proteins ATG13-101 in forming the autophagy initiation supercomplex.

Neutrophils in the brain are sources of neuroprotective molecules and demonstrate functional heterogeneity during chronic Toxoplasma gondii infection

This study identifies brain neutrophils as a source of neuroprotective molecules during chronic Toxoplasma gondii infection and reveals their functional heterogeneity based on age.

MDH2 is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle

This study identifies MDH2 as a metabolic switch that regulates NADH oxidation in the respiratory chain and TCA cycle by modulating OAA production and complex I/II activity.

Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency

This paper develops a method to control cytokine signaling using light-activated polymers that induce latency and release cytokines on demand.