Author

A. Liesz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Simats· 4 shared J. Cao· 3 shared S. Roth· 3 shared D. Brough· 2 shared J. P. Green· 2 shared J. Zhu· 2 shared N. Plesnila· 2 shared O. Carofiglio· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

A. Simats

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Innate immune memory after brain injury drives inflammatory cardiac dysfunction

A. Simats, S. Zhang, D. Messerer, J. Cao, F. Chong, S. Besson-Girard, O. Carofiglio, S. Filser, N. Plesnila, C. Braun, O. Gokce, M. Dichgans, K. Hatakeyama, B. Bonev, E. Beltran, , A. Liesz

This study identifies innate immune memory after brain injury as a driver of chronic cardiac dysfunction, showing that post-stroke epigenetic changes in myeloid cells lead to inflammation and fibrosis in the heart.

bioRxiv · Oct 4, 2023Immunology

Single-cell precision nanotechnology in vivo

M. MOLBAY, B. Kick, S. Zhao, M. I. Todorov, T.-L. Ohn, S. Roth, A. Simats, V. Singh, I. Khalin, C. Pan, H. Singh Bhatia, F. Hellal, R. Zeidler, A. Liesz, N. Plesnila, , A. Erturk

This study demonstrates DNA origami can be directed in vivo to target immune cells and cancer metastases, showing potential for precision drug delivery.

bioRxiv · Jul 24, 2023 · PreprintBioengineering

Infection-induced vascular inflammation in COVID-19 links focal microglial dysfunction with neuropathologies through IL-1/IL-6-related systemic inflammatory states

R. Fekete, A. Simats, E. Biro, C. Cserep, A. D. Schwarcz, B. Posfai, E. Szabadits, Z. Kornyei, K. Toth, A. Kellermayer, C. David, L. Acsady, L. Kontra, C. Silvestre-Roig, J. Moldvay, , A. Denes

bioRxiv · Jun 23, 2023 · PreprintImmunology

Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupture

J. Cao, S. Roth, S. Zhang, A. Kopczak, M. K. Georgakis, X. Li, A. Dutsch, T. G. Liman, M. Endres, D. Brough, J. P. Green, S. R. Wernsdorf, C. Fürle, O. Carofiglio, J. Zhu, , A. Liesz

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

bioRxiv · Feb 1, 2023 · PreprintImmunology

Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.

J. P. Green, L. Y. El-Sharkawy, S. Roth, J. Zhu, J. Cao, A. Leach, A. Liesz, S. Freeman, D. Brough

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

bioRxiv · Jul 28, 2022Immunology

T cells modulate the microglial response to brain ischemia

C. Benakis, A. Simats, S. Tritschler, S. Heindl, S. Besson-Girard, G. Llovera, K. Pinkham, A. Kolz, F. J. Theis, O. Gökce, A. Peters, A. Liesz

This study shows engineered T cells overexpressing IL-10 alter microglial gene expression to a pro-regenerative profile after stroke, highlighting T cell-microglia interactions in neuroinflammation.

bioRxiv · Sep 23, 2021Immunology