Elucidation of the essentiality of lumazine synthase (RibH) for Mycobacterium tuberculosis survival and discovery of potent inhibitors for enhanced antimycobacterial therapy
M. Singh, A. Dhanwal, A. Verma, L. Augustin, N. Kumari, S. Chakraborti, N. Agarwal, D. Sriram, R. J. Dey
This study validates the essentiality of RibH in M. tb survival and identifies three potent RibH inhibitors that show antimycobacterial activity and synergy with first-line TB drugs.
bioRxiv · Jul 18, 2023 · PreprintMicrobiology