N. Agarwal

Elucidation of the essentiality of lumazine synthase (RibH) for Mycobacterium tuberculosis survival and discovery of potent inhibitors for enhanced antimycobacterial therapy

This study validates the essentiality of RibH in M. tb survival and identifies three potent RibH inhibitors that show antimycobacterial activity and synergy with first-line TB drugs.

DNA origami 2.0

This study presents a method to grow silica shells on DNA origami structures, enhancing their stability while preserving their programmable features.

Designing a Cas9/gRNA-assisted quantitative Real-Time PCR (CARP) assay for identification of point mutations leading to rifampicin resistance in the human pathogen Mycobacterium tuberculosis

The paper develops a CARP assay using Cas9/gRNA to detect point mutations in Mtb's rpoB gene associated with rifampicin resistance through qRT-PCR.

ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma

This study identifies ISCA2 as a target for inhibiting HIF-1/2 and inducing ferroptosis in clear cell renal carcinoma, showing efficacy in xenograft models.

Human anelloviruses produced by recombinant expression of synthetic genomes.

This paper demonstrates the production of human anelloviruses in vitro using synthetic genomes in MOLT-4 cells, showing infectivity in mice and enabling further virology studies.

Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis

This study maps phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis, showing a biphasic mesenchymal response during de-differentiation and metabolic shifts.

Computational analysis reveals similarities and differences between SCLC subtypes

The paper analyzes SCLC subtypes using gene expression data to determine their similarities and differences, identifying co-expressed modules and classifying cell lines into clusters.

Versatile Encapsulation and Synthesis of Potent Therapeutic Liposomes by Thermal Equilibration

This paper introduces a thermal equilibration method to efficiently synthesize potent therapeutic liposomes with high drug loading and targeting capabilities.

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

Distinguishing Different Levels Of Consciousness using a Novel Network Causal Activity Measure

This study introduces a new measure of consciousness, Network Causal Activity, and finds it is higher in awake monkeys than under anaesthesia.