Author

F. Loehr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Knapp· 3 shared V. Doetsch· 3 shared A. Stolz· 2 shared B. Kuester· 2 shared V. V. Rogov· 2 shared A. C. Ravicahandran· 1 shared A. Chaikuad· 1 shared A. Doelle· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

S. Knapp

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Author profile →

4 papers

Recent·Most cited

Targeting LC3/GABARAP for degrader development and autophagy modulation

M. P. Schwalm, J. Dopfer, A. Kumar, F. A. Greco, N. Bauer, F. Loehr, J. Heering, S. Cano, S. Lechner, T. Hanke, I. Bekic, V. Morasch, D. Fearon, P. G. Marples, C. W. E. Tomlinson, , V. V. Rogov

The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.

bioRxiv · Oct 5, 2023 · PreprintBiochemistry

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

A. Doelle, B. Adhikari, A. Kraemer, J. Weckesser, N. Berner, L.-M. Berger, M. Diebold, M. Szewczyk, D. Barsyte-Lovejoy, C. Arrowsmith, J. Gerbel, F. Loehr, V. Doetsch, M. Eilers, S. Heinzlmeir, , S. Knapp

This study designs, synthesizes, and evaluates two series of WDR5 degraders, showing that linker length and nature affect degradation efficacy.

bioRxiv · Apr 12, 2021 · PreprintCancer Biology

p63 sets the threshold for induction of apoptosis using a kinetically encoded ‘doorbell-like’ mechanism

J. Gebel, M. Tuppi, A. Chaikuad, K. Hoette, L. Schulz, F. Loehr, N. Gutfreund, F. Finke, M. Schroeder, E. Henrich, J. Mezhyrova, R. Lehnert, F. Pampaloni, G. Hummer, E. H. K. Stelzer, , V. Doetsch

The paper shows that TAp63 uses a slow third phosphorylation step to set a threshold for apoptosis induction in response to DNA damage.

bioRxiv · Jun 24, 2019 · PreprintBiochemistry

Structural and Functional analysis of the GABARAP Interaction Motif (GIM).

V. V. Rogov, A. Stolz, A. C. Ravicahandran, A. Law, H. Suzuki, A. Kniss, D. O. Rios-Szwed, F. Loehr, S. Wakatsuki, V. Doetsch, I. Dikic, R. C. J. Dobson, D. McEwan

The paper identifies a GABARAP-specific interaction motif (GIM) and demonstrates its selectivity over LC3 using biophysical and structural analyses.

The EMBO Reports · Aug 1, 2017Peer-reviewedBiochemistry