Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division
S. Petracchini, D. Hamaoui, A. Doye, A. Asnacios, F. Fage, E. Vitiello, m. Balland, S. Janel, F. Lafont, M. Gupta, B. Ladoux, J. Gilleron, T. M. Maia, F. Impens, L. Gagnoux, , A. Mettouchi
This study shows OPTN regulates bacterial invasion by linking HACE1-mediated Rac1 ubiquitylation to integrin mechanotransduction and ECM stiffness.
bioRxiv · Sep 19, 2021Cell Biology