Author

F. Lafont

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

S. Janel· 3 shared A. Mettouchi· 2 shared E. Lemichez· 2 shared F. Rico· 2 shared M. Eroles· 2 shared A. Asnacios· 1 shared A. Bongiovanni· 1 shared A. Doye· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

S. Janel

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Reliable, standardized measurements for cell mechanical properties

S. Perez-Dominguez, S. G. Kulkarni, J. Pabijan, K. Gnanachandran, H. Holuigue, M. Eroles, E. Lorenc, M. Berardi, N. Antonovaite, M. L. Marini, J. Lopez Alonso, L. Redonto-Morata, V. Dupres, S. Janel, S. Acharya, , M. Lekka

The paper develops a standardized protocol for measuring mechanical properties of cancer cells using AFM, achieving consistent results across multiple laboratories.

bioRxiv · Jun 14, 2023Biophysics

Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages

M. Eroles, J. Lopez-Alonso, A. Ortega, T. Boudier, K. Gharzeddine, F. Lafont, A. Millet, C. Valotteau, F. Rico

This study uses mechanical and adhesion imaging to show that macrophages become stiffer and more adhesive than monocytes during differentiation.

bioRxiv · Nov 29, 2022Biophysics

Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation

M. Luciano, S.-L. Xue, W. H. De Vos, L. Redondo Morata, M. Surin, F. Lafont, E. Hannezo, S. Gabriele

This study shows that epithelial monolayers sense substrate curvature through changes in cell and nuclear shape, thickness, and YAP distribution, mediated by active cell mechanics and nuclear mechanoadaptation.

Nature Physics · Dec 1, 2021Peer-reviewedBiophysics

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division

S. Petracchini, D. Hamaoui, A. Doye, A. Asnacios, F. Fage, E. Vitiello, m. Balland, S. Janel, F. Lafont, M. Gupta, B. Ladoux, J. Gilleron, T. M. Maia, F. Impens, L. Gagnoux, , A. Mettouchi

This study shows OPTN regulates bacterial invasion by linking HACE1-mediated Rac1 ubiquitylation to integrin mechanotransduction and ECM stiffness.

bioRxiv · Sep 19, 2021Cell Biology

Docosahexaenoic fatty acid-containing phospholipids affect plasma membrane susceptibility to disruption by bacterial toxin-induced macroapertures

M.-C. TSAI, L. FLEURIOT, S. JANEL, D. GONZALEZ-RODRIGUEZ, C. MOREL, A. METTOUCHI, D. DEBAYLE, S. DALLONGEVILLE, J.-C. OLIVO-MARIN, B. ANTONNY, F. LAFONT, E. LEMICHEZ, H. BARELLI

The paper shows that DHA-containing phospholipids increase macroaperture formation in endothelial cells by reducing cell thickness, while maintaining overall transcellular area.

bioRxiv · Dec 23, 2020 · PreprintCell Biology

Rab11A regulates the constitutive secretory pathway during Toxoplasma gondii invasion of host cells and parasite replication.

K. Venugopal, S. Chehade, E. Werkmeister, N. Barois, J. Periz, F. Lafont, I. Tardieux, J. Khalife, G. Langsley, M. Meissner, S. MARION

This study identifies Rab11A's role in constitutive secretion and cargo transport during Toxoplasma gondii invasion and replication, revealing its impact on parasite motility and virulence.

bioRxiv · Sep 25, 2019Microbiology

ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival

M. Radulovic, A. Bongiovanni, K. O. Schink, V. Nähse-Kumpf, E. M. Wenzel, F. Lafont, H. Stenmark

The paper shows ESCRT machinery repairs damaged lysosomes before lysophagy, promoting cell survival and aiding intracellular pathogens.

bioRxiv · May 3, 2018Cell Biology

Biomechanical control of lysosomal secretion via the VAMP7 hub: a tug-of-war mechanism between VARP and LRRK1

G. Wang, S. Nola, S. Bovio, M. Coppey-Moisan, F. Lafont, T. Galli

The paper investigates how substrate rigidity affects VAMP7-mediated lysosomal secretion through a tug-of-war mechanism involving LRRK1 and VARP.

bioRxiv · Jul 4, 2017Cell Biology