Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes
C. Bernal-Mizrachi, J. Oh, A. E. Riek, K. T. Bauerle, A. Dusso, K. McNerney, R. Barve, I. Darwech, J. Sprague, C. Moynihan, R. M. Zhang, T. Wang, X. Xing, D. Li, R. D. Head, , M. S. Sands
The paper shows that embryonic vitamin D deficiency in HSCs leads to diabetes in mice by altering epigenetic pathways and macrophage function.
bioRxiv · Sep 8, 2022Physiology