A. Collins

Two dynamic, N-terminal regions are required for function in Ribosomal RNA Adenine Dimethylase family members

The paper identifies two N-terminal regions in RRAD enzymes critical for function, showing they promote rRNA binding and substrate positioning for methylation.

UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease.

This study shows that UCHL1 regulates HIF1 activity in liver fibrosis by cleaving ubiquitin chains, increasing HIF1 levels, and promoting fibrosis.

A cnidarian phylogenomic tree fitted with hundreds of 18S leaves

The paper constructs a cnidarian phylogenomic tree using 18S rRNA data and transcriptomes, confirming key relationships and proposing a new clade name.

Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes

The paper shows that embryonic vitamin D deficiency in HSCs leads to diabetes in mice by altering epigenetic pathways and macrophage function.

Truncated suPAR simultaneously causes kidney disease and autoimmune diabetes mellitus

The paper identifies a truncated suPAR fragment, D2D3, that causes kidney disease and autoimmune diabetes by impairing pancreatic beta-cell function and kidney health.

CXCR2 inhibition enables NASH-HCC immunotherapy

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

Determining and Predicting Soil Chemistry with a Point-of-Use Sensor Toolkit and Machine Learning Model

This paper develops a point-of-use sensor and machine learning model to predict soil nitrogen levels, improving fertilization planning and reducing overfertilization.

Ultra-Low-Cost Integrated Silicon-based Transducer for On-Site, Genetic Detection of Pathogens

This paper introduces a low-cost silicon-based transducer (TriSilix) for real-time, quantitative pathogen detection using PCR and RPA, demonstrating detection of SARS-CoV-2 and M. avium subsp. paratuberculosis at single-bacterium levels.

Pneumococcal Colonisation is an Asymptomatic Event in Healthy Adults using an Experimental Human Colonisation Model.

This study investigates whether pneumococcal colonisation in healthy adults is symptomatic using an experimental challenge model, finding it asymptomatic regardless of bacterial density or viral co-colonisation.

A conserved protein, BcmA, mediates motility, biofilm formation, and host colonisation in Adherent Invasive Escherichia coli

This paper identifies BcmA as a conserved protein essential for AIEC motility, biofilm formation, and host colonization, with implications for Crohn's Disease pathogenesis.

Ligand-Mediated Biofilm Formation via Enhanced Physical Interaction Between a Diguanylate Cyclase and Its Receptor

This paper shows that the DGC GcbC enhances c-di-GMP synthesis and biofilm formation through ligand-mediated interaction with its receptor LapD, with citrate increasing this interaction.

A Multimodal Strategy Used By A Large c-di-GMP Network

The paper investigates a large c-di-GMP network in Pseudomonas fluorescens, showing it uses multimodal regulation to control biofilm formation across nutrient conditions.