Parental-fetal interplay of immune genes leads to intrauterine growth restriction
G. Kaur, C. B. M. Porter, O. Ashenberg, J. Lee, S. J. Riesenfeld, M. Hofree, M. Aggelakopoulou, A. Subramanian, S. B. Kuttikkatte, K. E. Attfield, C. A. E. Desel, J. L. Davies, H. G. Evans, I. Avraham-Davidi, L. T. Nguyen, , L. Fugger
This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.
bioRxiv · Mar 26, 2021Immunology