Author

M. Hofree

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 4 Assay:scRNA-seq· 3 Assay:spatial transcriptomics· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Regev· 3 shared D. Dionne· 3 shared K. Pelka· 3 shared O. Rozenblatt-Rosen· 3 shared A. Mehta· 2 shared G. M. Boland· 2 shared I. Avraham-Davidi· 2 shared J. Chen· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

A. Regev

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Telocyte networks are an essential stem cell niche component in hair follicle regeneration

M. Canella, S. Nalick, A. Gharbi, A. Jamous, N. Corem, I. Ben-Porath, M. Hofree, M. Shoshkes Carmel

This study identifies telocyte networks as essential for hair follicle stem cell niche function through Wnt signaling and structural interactions during regeneration.

bioRxiv · May 17, 2023 · PreprintCell Biology

Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response

J. H. Chen, L. T. Nieman, M. Spurrell, V. Jorgji, P. M. Richieri, K. H. Xu, R. Madhu, M. Parikh, I. Zamora, A. Mehta, C. S. Nabel, S. S. Freeman, J. D. Pirl, C. Lu, C. B. Meador, , N. Hacohen

The paper identifies immune hubs in lung cancer that are associated with better responses to PD-1-blockade immunotherapy and contain stem-like CD8 T cells.

bioRxiv · Apr 4, 2023Immunology

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

I. Avraham-Davidi, S. Mages, J. Klughammer, N. Moriel, S. Imada, M. Hofree, E. Murray, J. Chen, K. Pelka, A. Mehta, G. M. Boland, T. M. Delorey, L. Caplan, D. Dionne, R. Strasser, , A. Regev

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

bioRxiv · Oct 2, 2022Cancer Biology

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

G. Kaur, C. B. M. Porter, O. Ashenberg, J. Lee, S. J. Riesenfeld, M. Hofree, M. Aggelakopoulou, A. Subramanian, S. B. Kuttikkatte, K. E. Attfield, C. A. E. Desel, J. L. Davies, H. G. Evans, I. Avraham-Davidi, L. T. Nguyen, , L. Fugger

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

bioRxiv · Mar 26, 2021Immunology

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

K. Pelka, M. Hofree, J. Chen, S. Sarkizova, J. D. Pirl, V. Jorgji, A. Bejnood, D. Dionne, W. H. Ge, K. H. Xu, S. X. Chao, D. R. Zollinger, D. J. Lieb, J. W. Reeves, C. A. Fuhrman, , J

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

bioRxiv · Jan 30, 2021 · PreprintCancer Biology

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

N. Baryawno, D. Przybylski, M. Kowalczyk, Y. Kfoury, N. Severe, K. Gustafsson, M. Francois, M. Tabaka, M. Hofree, D. Dionne, A. Papazian, D. Lee, O. Rozenblatt-Rosen, A. Regev, D. Scadden

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.

bioRxiv · Feb 21, 2019 · PreprintCell Biology

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

N. Chatterjee, E. Pazarentzos, G. Hrustanovic, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, V. Olivas, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, , T. G. Bivona

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

bioRxiv · Oct 11, 2018Cancer Biology