L. T. Nguyen

This paper introduces SAHARA, a CRISPR-Cas12a-based method for direct RNA detection without reverse transcription, showing improved specificity and multiplexing capabilities.

This paper develops a hydrogel-based GLP-1 receptor agonist delivery system that provides sustained therapy for up to 42 days in rats, improving diabetes management compared to daily injections.

This study investigates how excipients affect insulin stability and association state, finding that phenoxyethanol and specific copolymer concentrations enhance monomer content and stability in zinc-free insulin formulations.

This study identifies RNP1A as an RNA-binding protein that interacts with Contractility Kit proteins to support macropinocytosis in Dictyostelium discoideum.

This study identifies Anoctamin 9 as essential for mammalian olfaction, showing its role in amplifying olfactory signals and linking its downregulation to Covid-19-associated anosmia.

This study develops an ultra-fast insulin-pramlintide co-formulation that improves glucose management in diabetic rats by mimicking endogenous co-secretion and reducing patient burden.

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

This paper tests a natural oil blend (NOBF) against ASFV in porcine alveolar macrophages, finding it deactivates the virus at high dilutions.

The paper introduces LOV2GIVe, a modular protein that optogenetically activates Gi proteins using blue light, offering a new tool for precise G-protein manipulation.

The paper introduces an iSUF platform to enrich and purify tumor-derived extracellular vesicles from biofluids, showing high enrichment and biomarker expression in clinical samples.

This paper enhances Cas12a's trans-cleavage activity using engineered crRNAs, enabling sensitive nucleic acid detection without amplification, achieving femtomolar detection limits for DNA, RNA, and methylated DNA.

This study identifies HPnc4160, a small RNA in H. pylori, that negatively regulates host adaptation and gastric cancer by modulating gene expression and bacterial colonization.

The paper identifies a dynamic loop in cryptochromes that regulates their differential binding to CLOCK:BMAL1, explaining their distinct roles in circadian rhythms.

This study simulates two models of FtsZ-driven bacterial cell constriction to determine which mechanisms can sustain constriction under turgor pressure.

This study profiles microbial colonization and immune function transfer after fecal microbiota transplantation in IBD, revealing dynamic competition and immune interactions that influence clinical outcomes.

The paper uses simulations to show that a constrictive force is needed for Gram-negative bacterial cell division, as cell wall remodeling alone is insufficient.

The paper shows that the invariable site plus discrete Gamma model's parameters are poorly estimated by current software and proposes an improved optimization heuristic.

This study uses cryo-electron tomography to image the 3D structure of the actomyosin ring in fission yeast during cell division, revealing the arrangement of actin filaments.