G. Kaur

Insights into Human Norovirus Cultivation in Human Intestinal Enteroids

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

MicroRNA Tae-miR1130p targets wheat ferroportin1 (TaFPN1) in the absence of iron-responsive element/iron-regulatory protein1 module

The paper identifies tae-miR1130b-3p as a regulator of wheat FPN1, showing its negative correlation with TaFPN1 expression and suggesting an alternative regulatory mechanism in plant iron homeostasis.

Modular, Vascularized Hypertrophic Cartilage Constructsfor Bone Tissue Engineering Applications

This study develops modular, vascularized hypertrophic cartilage constructs for bone tissue engineering that support simultaneous mineralization and vessel formation without exogenous supplements.

Intermolecular Energy Migration via HomoFRET Captures the Modulation in the Material Property of Phase-Separated Biomolecular Condensates

This study uses homoFRET to measure material property changes in biomolecular condensates, showing how factors like RNA and post-translational modifications affect their structure.

Identifying the genetic and epigenetic basis for asymmetric bZIP expression in temperature-stressed bread wheat

This study investigates the genetic and epigenetic factors underlying asymmetric bZIP expression in bread wheat under temperature stress.

Rho and a riboswitch regulate mntP expression evading manganese stress and membrane toxicity

The paper shows Rho terminates transcription at the mntP riboswitch, and manganese activates the riboswitch to restore transcription-translation coupling, preventing membrane toxicity from overexpressed MntP.

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories

A Standardized Antiviral Pipeline for Human Norovirus in Human Intestinal Enteroids Demonstrates No Antiviral Activity of Nitazoxanide

This study tests nitazoxanide's antiviral activity against human noroviruses using a standardized pipeline in human intestinal enteroids, finding no significant antiviral effect.

Transcriptome and biochemical analysis pinpoint multi-layered molecular processes associated with iron deficiency tolerance in hexaploid wheat

This study identifies molecular and biochemical mechanisms underlying Fe deficiency tolerance in hexaploid wheat by comparing tolerant and susceptible cultivars.

Asymmetric expression of homoeologous genes in wheat roots modulates the early phase of iron-deficiency signalling

This study examines the transcriptional response of wheat roots to iron deficiency at early stages, identifying dynamic gene expression and homoeologous gene expression patterns.

An auto-inhibited state of protein kinase G and implications for selective activation

This study presents crystal structures of PKG Iβ in auto-inhibited and activated states, revealing the mechanism of cGMP-mediated activation and isoform-specific regulation.

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition for drought tolerance in Arabidopsis

This study identifies TaVIH2-3B, a wheat PPIP5K homolog, which enhances drought tolerance in Arabidopsis by modulating cell-wall composition through increased polysaccharide accumulation.

Plakoglobin and HMGB1 mediate intestinal epithelial cell apoptosis induced by Clostridioides difficile TcdB

This study identifies plakoglobin and HMGB1 as key mediators of TcdB-induced intestinal epithelial cell apoptosis through mitochondrial pathways.

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

MTOR promotes basal cell carcinoma growth through atypical PKC

The paper identifies MTOR as a driver of basal cell carcinoma growth by activating aPKC, showing that MTOR inhibition reduces tumor growth in mouse models.

p16-3MR: a novel model to study cellular senescence in cigarette smoke-induced lung injuries during aging

The paper demonstrates that p16-3MR mice are a suitable model to study cellular senescence in cigarette smoke-induced lung injuries and aging-related pathologies.

Protein Phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages

The paper investigates the role of Protein Phosphatase 1 (PP1) in atypical mitotic and meiotic divisions during Plasmodium sexual stages, suggesting PP1 inhibitors could block parasite transmission.

Anti-diabetic Potential of Aqueous Extract of Moringa oleifera, Ocimum gratissimum and Vernonia amygdalina in Alloxan-Induced Diabetic Rats

This study evaluates the antidiabetic effects of a triherbal formula in alloxan-induced diabetic rats, showing significant reductions in fasting blood glucose and hematological improvements.

Evaluation Of Biochemical, Hematological And Antioxidant Properties In Mice Exposed To A Triherbal (Nigella sativa, Carica papaya And Boswellia sacra) Formular

This study evaluates the effects of a triherbal formula on biochemical, hematological, and antioxidant properties in mice, finding dose-dependent decreases in hematological parameters and antioxidant activity.

Potential Hematotoxicity and Genotoxicity of Multi-Herbal Formulations in Albino Mice (Mus musculus)

This study evaluates the genotoxicity and hematotoxicity of three multi-herbal formulations in mice, finding dose-dependent increases in DNA fragmentation and micronucleated erythrocytes.

Physiological and molecular responses to combinatorial iron and phosphate deficiencies in hexaploid wheat seedlings

This study examines how hexaploid wheat responds to iron and phosphate deficiencies, finding that combined deficiencies rescue root growth inhibition and trigger specific gene and metabolite changes.

Gene expression pattern of vacuolar-iron transporter-like (VTL) genes in hexaploid wheat during metal stress

This study characterizes VTL genes in hexaploid wheat, showing their expression patterns under metal stress and their potential role in metal homeostasis.

Integrative analysis of hexaploid wheat roots identifies signature components during iron starvation

This study identifies gene and metabolic signatures in hexaploid wheat roots under iron starvation, revealing key transporters and metabolites involved in Fe acquisition and response.

Tunability of DNA polymerase stability during eukaryotic DNA replication

The paper shows how DNA polymerase stability and exchange dynamics in the yeast replisome are tuned by local concentrations, enabling efficient replication and adaptation to genomic challenges.

Overlapping transcriptional expression response of wheat zinc-induced facilitator-like transporters emphasize important role during Fe and Zn stress

The paper identifies and analyzes wheat ZIFL transporters, showing their differential expression under Fe and Zn stress and heavy metal exposure.

Nuclease dead Cas9 is a programmable roadblock for DNA replication

The paper uses a modified Cas9 protein to create a programmable roadblock for studying DNA replication fork arrest in vitro and in vivo.

Comparison of Small Gut and Whole Gut Microbiota of First-Degree Relatives with Adult Celiac Disease Patients and Controls

The paper compares gut microbiota of first-degree relatives of celiac disease patients with patients and controls, finding specific taxonomic and functional differences in the duodenum and fecal samples.

Cell-intrinsic genetic regulation of peripheral memory-phenotype T cell frequencies

The paper shows memory T cell frequencies are genetically regulated and stable over time, while recently activated cells are influenced by environmental factors.