Cell BiologybioRxiv
Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells
A. Islam, Y.-C. Chang, X.-C. Chen…·P. J. Chueh
This study identifies 4-dmH, a water-soluble heliomycin derivative, as more effective than parental heliomycin in oral cancer by targeting the tNOX-SIRT1 axis and inducing apoptosis.
DOI 10.7554/elife.87873