A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer
L. Bajaj, A. di Ronza, P. Zheng, A. Eblimit, R. Pal, J. Sharma, D. Roman, J. R. Collette, R. N. Sifers, S. Y. Jung, R. Chen, R. Schekman, M. Sardiello
The paper identifies CLN6 and the EGRESS complex as essential for lysosomal enzyme trafficking from the ER to the Golgi, revealing their role in Batten disease pathogenesis.
bioRxiv · Sep 18, 2019Cell Biology