R. Pal

Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection

This study designs triazole inhibitors targeting M. tuberculosis's histidine biosynthesis pathway, showing efficacy against drug-resistant strains and reducing bacterial burden in infected mice.

In Vitro Activity of Cysteamine Against SARS-CoV-2 Variants

This study shows cysteamine HCl inhibits multiple SARS-CoV-2 variants in vitro, suggesting potential as a topical nasal treatment to mitigate infection and transmission.

Atomic-Resolution Prediction of Degrader-mediated Ternary Complex Structures by Combining Molecular Simulations with Hydrogen Deuterium Exchange

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

Hemoglobin drives inflammation and initiates antigen spread and nephritis in lupus

This study shows that hemoglobin, particularly ferric hemoglobin, drives inflammation and autoantibody production in lupus by interacting with autoantigens and activating immune cells.

Detection of urinary metabolites of metabolic pathway disorders by using VTGE and LC-HRMS techniques

The paper introduces a method combining VTGE and LC-HRMS to detect metabolites in urine for metabolic disorder diagnosis, showing its effectiveness in identifying specific biomarkers.

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

The paper identifies CLN6 and the EGRESS complex as essential for lysosomal enzyme trafficking from the ER to the Golgi, revealing their role in Batten disease pathogenesis.

CELF1 is an EIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs

The paper shows CELF1 binds eIF4E and PABP to promote translation of EMT effector mRNAs, and disrupting this interaction inhibits EMT and metastasis.

Nitric oxide sensing by chlorophyll a

The paper proposes using chlorophyll a to sense and classify different nitric oxide species with high sensitivity and temperature dependence.