L. Pan

Native β-barrel substrates pass through two shared intermediates during folding on the BAM complex

The paper uses a disulfide crosslinking method to identify shared intermediates in the folding of diverse β-barrel substrates by the BAM complex in E. coli.

A smartphone-based genetically recombinant whole-cell biosensor for highly sensitive monitoring of polychlorinated biphenyls (PCBs)

This paper develops a genetically engineered whole-cell biosensor using E. coli to detect multiple PCB congeners with high sensitivity, and integrates it with a smartphone for real-time monitoring.

Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts

This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.

A rapid and efficient in vivo inoculation method for introducing tree stem canker pathogens onto leaves: Suitable for large-scale assessment of resistance in poplar breeding progeny

This paper introduces an in vivo leaf inoculation method for assessing poplar resistance to V. sordida, showing it is more efficient and suitable for large-scale screening than traditional stem segment inoculation.

In-silico Drug Repurposing pipeline for Epilepsy: Integrating Deep Learning and Structure-based Approaches

This paper develops an in-silico drug repurposing pipeline for epilepsy using deep learning and structure-based methods, identifying potential drugs with high binding affinity for epilepsy-related targets.

Molecular Mechanism of PP2A/B55α Phosphatase Inhibition by IER5

This study determines the structure of PP2A/B55 inhibited by IER5-N50 and shows its role in suppressing pTau dephosphorylation and KRT1 expression.

Ancient Sheep Genomes reveal four Millennia of North European Short-Tailed Sheep in the Baltic Sea region

This study analyzes ancient sheep genomes from the Baltic Sea region to show long-term continuity of short-tailed breeds and loss of genetic diversity in modern times.

Virological characteristics of the SARS-CoV-2 Omicron XBB.1.16 variant

This study characterizes the virological features of the SARS-CoV-2 Omicron XBB.1.16 variant, showing increased transmissibility and immune evasion compared to previous variants.

Homeostatic control of an iron repressor in a GI tract resident

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

Anatomical drivers of stomatal conductance in sorghum lines with different leaf widths grown under different temperatures

The paper examines how leaf width and temperature affect stomatal conductance and anatomical traits in sorghum, finding narrower leaves have lower stomatal conductance and higher water use efficiency.

Macrophage migrates on alternate non-adhesive surfaces

This study shows macrophages can migrate across non-adhesive PEG surfaces by adopting a mesenchymal mode, overcoming the limitations seen in other cell types.

FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

Understanding the Dynamics of Fluid-Structure Interaction with an Air Deflected Microfluidic Chip (ADMC)

The paper couples a deformable microfluidic system with a fluidic dynamic model to study fluid-structure interaction in transient flow, showing the model predicts liquid displacement dynamics and identifies overshooting and oscillation phenomena relevant to dentine hypersensitivity.

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

This study shows that TH5487, an OGG1 inhibitor, reduces allergic airway inflammation in mice by decreasing mucus production, immune cell recruitment, and proinflammatory cytokines.

Metformin decreases Cyp26a1 to prevent hepatocarcinogenesis through down- regulating CD8+ T cells

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant

This paper develops a ferritin-based nanoparticle vaccine targeting the SARS-CoV-2 Omicron variant, showing enhanced immunogenicity compared to a non-nanoparticle version.

Efficient inactivation of African swine fever virus by a highly complexed iodine combined with compound organic acids

This study evaluates the effectiveness of a disinfectant combining highly complexed iodine and compound organic acids in inactivating African swine fever virus under various conditions, showing dose- and time-dependent inactivation with synergistic effects.

Activin A correlates with the worst outcomes in COVID-19 patients, and can be induced by cytokines via the IKK/NF-kappa B pathway

The paper shows elevated Activin A and FLRG levels in COVID-19 patients predict severe outcomes like mechanical ventilation and mortality.

Downregulation of Perilipin1 by IMD leads to LD reconfiguration and adaptation to bacterial infection in Drosophila

The paper shows that IMD/Relish suppresses perilipin1, leading to lipid droplet enlargement that reduces ROS stress during bacterial infection in Drosophila.

Lateral mechanical impedance rather than frontal, promotes cortical expansion of roots

The paper shows that lateral mechanical impedance, not frontal, promotes cortical expansion and radial growth in maize roots.

IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation

The paper identifies IER5 as a Notch-induced DNA-damage response gene required for squamous cell differentiation and shows its interaction with PP2A subunit PPP2R2A.

Exifone is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

This paper identifies exifone as a potent HDAC1 activator that provides neuroprotection in human neuronal models of neurodegeneration by enhancing deacetylase activity and reducing histone acetylation.

LanD-like Flavoprotein-Catalyzed Aminovinyl-Cysteine Formation through Oxidative Decarboxylation and Cyclization of a Peptide at the C-Terminus

This paper identifies a dual activity in LanD-like flavoproteins for forming aminovinyl-cysteine residues through oxidative decarboxylation and cyclization of peptides.

DNA-mediated assembly of multi-specific antibodies for T cell engaging and tumor killing

This paper describes a method to assemble multi-specific antibodies using DNA-mediated assembly, showing efficacy in tumor cell cytotoxicity and xenograft suppression.

An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal

The paper identifies an inflammatory CD4 T cell subset and transcriptomic signatures in JIA patients in remission that predict relapse after anti-TNFα withdrawal.

Hypotonic stress induces fast, reversible degradation of the vimentin cytoskeleton via intracellular calcium release

The paper shows hypotonic stress causes rapid, reversible vimentin cytoskeleton degradation via calcium release and calpain proteolysis, preceding changes in other cytoskeletal systems.

Androgen-dmrt1 positive feedback programs the rice field eel (Monopterus albus) sex transdifferentiation

This study identifies androgen-dmrt1 positive feedback as a mechanism driving sex reversal in rice field eel by analyzing gene regulation and enzyme expression.

Infection of Plasmodiophora brassicae changes the fungal endophyte community of tumourous stem mustard roots as revealed by high-throughput sequencing and culture-dependent methods

This study examines how Plasmodiophora brassicae infection alters the fungal endophyte community in stem mustard roots using sequencing and culture methods, finding reduced diversity and shifts in dominant taxa.

Allosteric Role of Substrate Occupancy Toward the Alignment of P-glycoprotein Nucleotide Binding Domains

This study investigates how substrate occupancy in P-glycoprotein influences NBD dimerization through molecular dynamics simulations, showing improved alignment with drug binding.