OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice
L. Tanner, J. Bergwik, R. K. Bhongir, L. Pan, C. Dong, C. Kalderen, T. Helleday, I. Boldogh, M. Adner, A. Egesten
This study shows that TH5487, an OGG1 inhibitor, reduces allergic airway inflammation in mice by decreasing mucus production, immune cell recruitment, and proinflammatory cytokines.
bioRxiv · May 17, 2022 · PreprintPharmacology & Toxicology