Evolution of an interaction between disordered proteins resulted in increased heterogeneity of the binding transition state
E. Karlsson, C. Paissoni, A. Erkelens, Z. A. Tehranizadeh, F. A. Sorgenfrei, E. Andersson, W. Ye, C. Camilloni, P. Jemth
The paper compares the binding transition states of ancestral and human IDP domains, finding increased heterogeneity in the human complex.
bioRxiv · Mar 27, 2020Biophysics