E. Karlsson

Bacterial community characterization by deep learning aided image analysis in soil chips

This paper uses deep learning to analyze bacterial communities in soil chips from three locations, quantifying abundance and morphology to study population dynamics and biodiversity.

Airborne eDNA captures three decades of ecosystem biodiversity

The paper develops a method using airborne eDNA sequencing to monitor biodiversity over 34 years, detecting over 2,700 genera and revealing regional biodiversity declines.

Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor

The paper identifies a stimulant derivative binding in a cryptic vestibular pocket of the 5-HT3A receptor using computational and experimental methods.

Temperature moderates eDNA-biomass relationships in northern pike

This study examines how temperature affects the relationship between eDNA concentrations and northern pike biomass in coastal bays, finding that temperature moderates eDNA-biomass dynamics.

Using evolutionary constraint to define novel candidate driver genes in medulloblastoma

The paper identifies novel candidate driver genes in medulloblastoma by analyzing non-coding constraint mutations across pediatric brain tumors and comparing them to benign tumors.

Three-dimensional genome re-wiring in loci with Human Accelerated Regions

The paper identifies human-specific 3D genome re-wiring in conserved loci, linking accelerated evolution to regulatory rewiring in neural progenitor cells.

The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved

The paper compares the dynamic properties of an ancient NCBD from a bilaterian ancestor to human NCBD, finding conserved dynamics despite increased thermodynamic stability.

Evolution of an interaction between disordered proteins resulted in increased heterogeneity of the binding transition state

The paper compares the binding transition states of ancestral and human IDP domains, finding increased heterogeneity in the human complex.

Helix formation during the coupled binding and folding of intrinsically disordered proteins monitored by synchrotron-radiation circular dichroism spectroscopy

The paper uses synchrotron-radiation circular dichroism to study helix formation during the binding of intrinsically disordered proteins, revealing kinetic phases and structural intermediates.

How to make a rodent giant: Genomic basis and tradeoffs of gigantism in the capybara, the world’s largest rodent

This study sequenced the capybara genome to investigate the genetic basis of gigantism and related tradeoffs, finding elevated mutation load and novel anticancer mechanisms.