The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease
D. Guisado, S. Talware, X. Wang, A. Davis, E. Fozilov, A. Etra, J.-F. Colombel, C. Schaniel, C. Tasad, J. E. Levine, J. L. M. Ferrara, L.-S. Chuang, K. Sabic, S. Singh, B. K. Marcellino, , L. Cohen
This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.
bioRxiv · May 30, 2024 · PreprintImmunology