A. Davis

The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

SenPred: A single-cell RNA sequencing-based machine learning pipeline to classify senescent cells for the detection of an in vivo senescent cell burden

SenPred uses scRNA-seq to classify senescent cells and detects in vivo senescent cell burden with high accuracy.

Intraspecific trait variation modulates the temperature effect on elemental quotas and stoichiometry in marine Synechococcus

This study shows that intraspecific variation in Synechococcus affects elemental quotas and stoichiometry more than temperature changes.

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.

Multiple metals influence distinct properties of the Arabidopsis circadian clock

The paper examines how different metal salts affect the circadian clock in Arabidopsis using promoter:luciferase systems and analyzes the results with Fourier and wavelet-based methods.

The retromer complex regulates C. elegans development and mammalian ciliogenesis

This study shows the retromer complex is essential for C. elegans development and mammalian ciliogenesis, with a role in CP110 removal from the mother centriole.

Respiratory bacteria stabilize and promote airborne transmission of influenza A virus

This study shows that respiratory bacteria enhance the stability and transmission of influenza A virus through direct interactions.

Evaluation of the functional role of the maize Glossy2 and Glossy2-like genes in cuticular lipid deposition

Transgenic experiments show Gl2-like and Gl2 genes in maize have overlapping but divergent roles in cuticular lipid deposition, with Gl2-like requiring a catalytic motif for function.

Optimal spatial prioritization of control resources for elimination of invasive species under demographic uncertainty

This study shows that optimal resource allocation for invasive species control depends on connectivity structure, damage function, and observational uncertainty, with improved monitoring being most beneficial under moderate budgets.

Photoperiod sensing of the circadian clock is controlled by ELF3 and GI

This study shows ELF3 and GI are essential for circadian clock-mediated photoperiod sensing in Arabidopsis.

Accounting for location uncertainty in azimuthal telemetry data improves ecological inference

The paper introduces a novel azimuthal telemetry model to account for location uncertainty in ecological analyses and shows its benefits over existing methods.

Detection of Pro-apoptotic BaxΔ2 Proteins in the Human Cerebellum

The paper reports the presence of BaxΔ2 protein in human cerebellar tissues, with varying expression levels across Purkinje cells and associated genetic mutations.

An epigenetic mechanism for cavefish eye degeneration

The paper identifies DNA methylation-based epigenetic silencing as a mechanism causing eye degeneration in blind cavefish and links these genes to human eye disorders.