J. Cho

The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of influenza A virus

This study analyzes how mutations in the NS1 protein of influenza A virus rewired allosteric and epistatic networks, enhancing its binding affinity to p85β.

An Enterobacteriaceae bloom in aging animals is restrained by the gut microbiome

The paper identifies an Enterobacteriaceae bloom in aging animals as a common feature, showing its link to immune decline and susceptibility to infection, while highlighting the role of commensal competition in healthy aging.

Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron variants

This study evaluates the antiviral efficacy of remdesivir, molnupiravir, and nirmatrelvir against newly emerged SARS-CoV-2 Omicron subvariants and finds they retain antiviral activity.

Poly(A) tail length regulation by mRNA deadenylases is critical for suppression of transposable elements

This study shows that RNA deadenylation by the CCR4-NOT complex is critical for suppressing transposable elements in Arabidopsis, independent of small RNA targeting.

IMPASTO: Multiplexed cyclic imaging without signal removal via self-supervised neural unmixing

IMPASTO enables erasureless cyclic imaging for multiplexed spatial proteomics through self-supervised neural unmixing, achieving 30-plex imaging with reduced tissue distortion.

Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

This study shows dapagliflozin improves hemodynamics and endothelial integrity in endotoxin-treated mice via the ApoM/S1P pathway by preserving megalin expression.

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

This study compares the infectivity of SARS-CoV-2 variants in human alveolar cells, finding Omicron (BA.1) to be 3-5-fold more infectious than other variants at early infection.

m6A RNA methylation impairs gene expression variability and reproductive thermotolerance in Arabidopsis

This study shows that m6A RNA methylation reduces gene expression variability and impairs reproductive thermotolerance in Arabidopsis under heat stress.

Suppression of transposon mobilization by m6A-mediated RNA sequestration in stress granules

This study shows that m6A RNA methylation sequesters transposon RNA in stress granules, preventing mobilization, and that demethylation by AtALKBH9B allows transposon activation.

Vascular tropism models of blood-borne microbial dissemination

This study investigates how B. burgdorferi strains interact with different vascular tissues and predicts their in vivo dissemination patterns based on vascular interaction properties.

Computer-Vision Stabilized Intravital Imaging Reveals Lung Capillary Neutrophil Dynamics Crucial for Lung Host-Defense Function

This study uses CASTii to analyze lung capillary neutrophil dynamics, revealing their role in host defense and response to infection.

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.

The paper develops three RORγt inhibitors that reduce Th17 differentiation and inflammation in vivo and inhibit tumor growth in PDAC organoids.

Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

This study develops multiantigen recognition circuits for CAR T cells to improve specificity, heterogeneity, and durability in glioblastoma treatment.

Pyronaridine and artesunate are potential antiviral drugs against COVID-19 and influenza

This study identifies pyronaridine and artesunate as potential antiviral drugs effective against SARS-CoV-2 and influenza viruses in human lung cells.

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

Translational inhibition and phase separation primes the epigenetic silencing of transposons

The paper shows that ribosome stalling and phase separation are critical for transposon RNA processing and epigenetic silencing in plants.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

Sensitive detection of pre-integration intermediates of LTR retrotransposons in crop plants

This paper introduces ALE-seq to detect pre-integration intermediates of LTR retrotransposons in crop plants and identifies heat-activated and developmentally regulated retrotransposons.