BiochemistrybioRxiv
Functional and structural characterization of allosteric activation of Phospholipase Cϵ by Rap1A
M. Sieng, A. F. Selvia, E. E. Garland-Kuntz…·A. Lyon
This study shows Rap1A allosterically activates PLCε by stabilizing interactions between the RA2 domain and the PLC core, confirmed through biochemical and structural analyses.
DOI 10.1074/jbc.ra120.015685