Author

G. Otting

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:virus· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

C. J. Jackson· 2 shared C. Nitsche· 2 shared S. Ullrich· 2 shared A. Aggarwal· 1 shared A. Ashhurst· 1 shared A. Feintuch· 1 shared B. E. Clifton· 1 shared D. Goldfarb· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

C. J. Jackson

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Author profile →

3 papers

Recent·Most cited

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir (PF-07321332)

S. Ullrich, K. B. Ekanayake, G. Otting, C. Nitsche

This study shows that nirmatrelvir remains effective against Mpro variants from current SARS-CoV-2 lineages.

bioRxiv · Nov 28, 2021Biochemistry

Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display

J. Johansen-Leete, S. Ullrich, S. Fry, R. Frkic, M. Bedding, A. Aggarwal, A. Ashhurst, K. Ekanayake, M. Mahawaththa, V. Sasi, T. Passioura, M. Larance, G. Otting, S. G. Turville, C. J. Jackson, , R. J. Payne

This study identifies cyclic peptides targeting SARS-CoV-2 main protease using mRNA display, showing antiviral activity in vitro.

bioRxiv · Aug 23, 2021Biochemistry

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

J. A. Kaczmarski, M. C. Mahawaththa, A. Feintuch, B. E. Clifton, L. A. Adams, D. Goldfarb, G. Otting, C. J. Jackson

The paper investigates how remote mutations alter conformational sampling along an evolutionary trajectory, increasing catalytic activity in an enzyme.

bioRxiv · Feb 3, 2020Biochemistry