Author

A. Filloux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

D. A. I. Mavridou· 2 shared D. Mavridou· 2 shared P. Bernal· 2 shared R. C. D. Furniss· 2 shared A. Dobbelstein· 1 shared A. K. Cain· 1 shared A. K. Tarafder· 1 shared A. von Kugelgen· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

D. A. I. Mavridou

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8 papers

Recent·Most cited

Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

N. Kaderabkova, R. C. D. Furniss, E. Maslova, K. E. Potter, L. Eisaiankhongi, P. Bernal, A. Filloux, C. Landeta, D. Gonzalez, R. R. McCarthy, D. Mavridou

The paper identifies cell envelope protein homeostasis pathways as key to antibiotic resistance and cross-protection in CF-associated bacteria, showing potential for new treatment strategies.

bioRxiv · Aug 2, 2023Microbiology

Effectiveness of Pseudomonas aeruginosa type VI secretion system relies on toxin potency and type IV pili-dependent interaction

M. Rudzite, R. Endres, A. Filloux

This study investigates how the effectiveness of Pseudomonas aeruginosa's type VI secretion system depends on toxin potency and type IV pili-mediated interactions in competitive bacterial communities.

bioRxiv · Nov 30, 2022 · PreprintMicrobiology

Characterization of TelE, an LXG effector exhibiting a conserved C-terminal glycine zipper motif required for toxicity

W. K. Teh, Y. Ding, F. Gubellini, A. Filloux, C. Poyart, M. Givskov, S. Dramsi

The paper identifies and characterizes TelE, an LXG effector from SGG with pore-forming activity, showing its toxicity and requirement for a conserved glycine zipper motif.

bioRxiv · Sep 7, 2022Microbiology

Architecture of the biofilm-associated archaic CupE pilus from Pseudomonas aeruginosa

J. Boehning, A. Dobbelstein, N. Sulkowski, K. Eilers, A. von Kugelgen, A. K. Tarafder, V. Alva, A. Filloux, T. A. M. Bharat

This study presents the structure of the archaic CupE pilus from Pseudomonas aeruginosa, revealing its zigzag architecture and role in biofilm formation.

bioRxiv · Apr 14, 2022Microbiology

Structure of ATP synthase from ESKAPE pathogen Acinetobacter baumannii

J. K. Demmer, B. P. Phillips, O. L. Uhrig, A. Filloux, L. P. Allsopp, M. Bublitz, T. Meier

The paper determines the cryo-EM structures of ATP synthase from Acinetobacter baumannii in three conformational states, identifying potential therapeutic targets.

bioRxiv · Jul 10, 2021Biochemistry

Novel structural components generate distinct type VI secretion system anchoring modes

P. Bernal, R. C. D. Furniss, S. Fecht, R. C. Y. Leung, L. Spiga, D. A. I. Mavridou, A. Filloux

The paper identifies novel structural components that stabilize short TssA-containing T6SSs, leading to distinct firing behaviors and aggression strategies in bacteria.

bioRxiv · Apr 29, 2020Microbiology

Fast and robust detection of colistin resistance in Escherichia coli using the MALDI Biotyper Sirius mass spectrometry system

R. C. Furniss, L. Dortet, W. Bolland, O. Drews, K. Sparbier, R. Bonnin, A. Filloux, M. Kostrzewa, D. Mavridou, G. Larrouy-Maumus

This study adapts the MALDIxin test for the MALDI Biotyper Sirius system to rapidly and reliably detect colistin resistance in E. coli clinical isolates.

bioRxiv · Aug 30, 2019Microbiology

Discovery of a Pseudomonas aeruginosa Type VI secretion system toxin targeting bacterial protein synthesis using a global genomics approach

L. M. Nolan, A. K. Cain, E. Manoli, M. A. Sainz-Polo, G. Dougan, D. A. I. Mavridou, D. Albesa-Jove, J. Parkhill, A. Filloux

The paper uses TraDIS to identify T6SS toxins in Pseudomonas aeruginosa, finding Tse8 targets bacterial protein synthesis by disrupting the transamidosome complex.

bioRxiv · Aug 13, 2019 · PreprintMicrobiology