Y. Ding

Classifying Resting State Connectivity: Lag-One Autocorrelation and Pattern Differentiability

This study compares resting state functional connectivity (rsFC) and effective connectivity (rsEC) for classifying psychiatric conditions, finding rsEC performs worse than rsFC and autocorrelation affects classification accuracy.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes

This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.

Conserved mycobacterial sRNA B11 regulates lipooligosaccharide synthesis at post-transcriptional level

This study identifies B11, a conserved mycobacterial sRNA, as a post-transcriptional regulator of lipooligosaccharide synthesis, revealing its mechanism of action through RNA-seq and mass spectrometry.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Neuromechanical Phase Lags and Gait Adaptation in the Nematode C. elegans

This study measures neuromechanical phase lags in C. elegans and shows they are controlled by body elasticity and environmental forces, shaping gait.

Super homotypic targeting by exosome surface engineering

This paper enhances homotypic targeting by engineering exosome surfaces with lanthanides, significantly improving cell-exosome interactions and enabling new applications in diagnostics and therapy.

The enhancement of electricity generation using cellulose based on ternary microbial consortium

This paper demonstrates that a ternary microbial consortium enhances electricity generation from cellulose by synergistically converting it to acetate and using riboflavin as an electron shuttle.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Loss of Lkb1 cooperates with BrafV600E and UV radiation increasing melanoma multiplicity and neural-like dedifferentiation

CPT1A Mediates Radiation Sensitivity in Colorectal Cancer

This study identifies CPT1A as a mediator of radiation sensitivity in colorectal cancer, showing its role in ROS scavenging and DNA damage response through the FOXM1-SOD1/SOD2/CAT axis.

A new group of LysM-RLKs involved in symbiotic signal perception and arbuscular mycorrhiza establishment

The paper identifies a new group of LysM-RLK receptors that bind both LCO and CO, playing a complementary role with LYR-IA receptors in arbuscular mycorrhiza formation.

Mechanisms mediating arylidene-indolinones induced degradation: thoughts on "Discovery of a Drug-like, Natural Product-Inspired, DCAF11 Ligand Chemotype"

The paper discusses discrepancies in conclusions about arylidene-indolinones' mechanism of action, suggesting possible explanations for conflicting findings on their role as DCAF11 ligands and autophagy-tethering compounds.

Replicating enzymatic activity by positioning active sites with synthetic protein scaffolds

The paper demonstrates a computational strategy to design new PET hydrolases by replicating functional motifs from a template enzyme using deep learning and molecular computations, resulting in enzymes with high activity and thermostability.

Changes in the cellular makeup of motor patterning circuits drive courtship song evolution in Drosophila

The paper investigates how changes in motor patterning circuits and cell types contribute to the evolution of courtship song in Drosophila species.

Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation

This study identifies GRP7 as a key regulator of ABA-mediated translation efficiency in Arabidopsis by modulating pre-rRNA processing and ribosome distribution.

Song Torrent: A modular, open-source 96-chamber audio and video recording apparatus with optogenetic activation and inactivation capabilities for Drosophila

The paper describes a modular, open-source system for high-throughput audio and video recording of Drosophila courtship behavior with optogenetic capabilities.

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

Ancestral neural circuits potentiate the origin of a female sexual behavior

The paper identifies a neural circuit in Drosophila santomea that co-opts an ancestral circuit to drive a new female sexual behavior through social feedback.

Comparison of tet(X4)-containing contigs from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjects.

This study compares tet(X4)-containing contigs from metagenomic data with plasmid sequences from isolates in a healthy cohort, finding high similarity and co-occurrence of resistance genes.

A polydiolcitrate-MoS2 composite for 3D printing Radio-opaque, Bioresorbable Vascular Scaffolds

This paper develops a polydiolcitrate-MoS2 composite for 3D printing bioresorbable vascular scaffolds that are X-ray visible and suitable for non-invasive monitoring.

3D-printed, Citrate-based Bioresorbable Vascular Scaffolds for Coronary Artery Angioplasty

This paper develops a drug-eluting bioresorbable vascular scaffold with reduced strut thickness and controlled drug release, showing comparable pre-clinical performance to metallic stents.

Investigation of 3D Printed Bioresorbable Vascular Scaffold Crimping Behavior

The paper develops a simulation tool using ABAQUS to analyze the crimping behavior of 3D-printed bioresorbable vascular scaffolds, enabling faster design evaluation than experimental testing.

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

The paper identifies GIF/metallothionein-3 as a sulfane sulfur-binding protein that regulates zinc ion binding and release through a unique C-S-S-Zn structure.

DP/MM: A Hybrid Model for Zinc-Protein Interactions in Molecular Dynamics

This paper introduces DP/MM, a hybrid model for zinc-protein interactions that improves accuracy and efficiency in molecular dynamics simulations.

High-throughput generic single-entity sequencing using droplet microfluidics

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

Comparison of robotic automated and manual injection methods in zebrafish embryos for high throughput RNA silencing using CRISPR-CasRx

This study compares robotic and manual injection methods for CRISPR-CasRx RNA knockdown in zebrafish embryos, finding similar efficiency and phenotype rates between approaches.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.