Mechanisms underlying neonate specific metabolic effects of volatile anesthetics
J. Stokes, A. Freed, A. Pan, G. X. Sun, R. Bornstein, J. Snell, K. Y. Park, P. G. Morgan, M. M. Sedensky, S. C. Johnson
This study identifies a neonate-specific metabolic effect of volatile anesthetics, showing they deplete beta-hydroxybutarate at sub-anesthetic concentrations, mediated by citrate and malonyl-CoA changes, which adults are less sensitive to.
bioRxiv · Dec 8, 2020Physiology