A. Pan

Ellagic acid: a potential inhibitor of enhancer of zeste homolog-2 and protein arginine methyltransferase-5

This study identifies ellagic acid as an inhibitor of EZH2 and PRMT5:MEP50, showing reduced histone modifications and tumor growth in mouse models.

Epigallocatechin-3-gallate inhibit the protein arginine methyltransferase 5 and Enhancer of Zeste homolog 2 in breast cancer both in vitro and in vivo

This study shows that EGCG inhibits PRMT5 and EZH2 in breast cancer cells and xenografts, reducing histone repressive marks and inducing apoptosis and autophagy.

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

A platform for dissecting force sensitivity and multivalency in actin networks

This paper develops an in vitro platform to study how mechanical forces affect actin-binding protein interactions in multi-filament networks, revealing that force enhances -catenin binding to small filament bundles.

Heavy-chain CDR3-engineered B cells facilitate in vivo evaluation of HIV-1 vaccine candidates

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape

This study shows that succinate from commensal protists activates tuft cells, leading to changes in antimicrobial peptides and microbiota composition in the small intestine.

Mechanisms underlying neonate specific metabolic effects of volatile anesthetics

This study identifies a neonate-specific metabolic effect of volatile anesthetics, showing they deplete beta-hydroxybutarate at sub-anesthetic concentrations, mediated by citrate and malonyl-CoA changes, which adults are less sensitive to.

Mutanofactin promotes bacterial adhesion and biofilm formation of cariogenic Streptococcus mutans

The paper identifies mutanofactin-697, a secondary metabolite from S. mutans, which promotes biofilm formation by increasing bacterial hydrophobicity and adhesion.