PhysiologybioRxiv
Mechanisms underlying neonate specific metabolic effects of volatile anesthetics
J. Stokes, A. Freed, A. Pan…·S. C. Johnson
This study identifies a neonate-specific metabolic effect of volatile anesthetics, showing they deplete beta-hydroxybutarate at sub-anesthetic concentrations, mediated by citrate and malonyl-CoA changes, which adults are less sensitive to.
DOI 10.7554/elife.65400