MicrobiologybioRxiv
Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades
B. Dadonaite, J. Brown, T. E. McMahon…·J. D. Bloom
This study uses deep mutational scanning to assess how mutations in SARS-CoV-2 spike proteins affect ACE2 binding, cell entry, and serum escape, linking these effects to clade growth rates.
DOI 10.1038/s41586-024-07636-1