P. Zhou

Identification of P-type ATPase as a bacterial transporter for host-derived small RNA

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.

Inhibition of serine racemase prevents diabetic retinopathy

This study shows that inhibiting serine racemase with L-ABH prevents diabetic retinopathy by protecting retinal cells and maintaining glucose homeostasis in diabetic mice.

Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic adenocarcinoma

This paper shows that combining HDAC and eIF4A inhibitors effectively treats pancreatic cancer by inducing epigenetic reprogramming and metabolic stress in preclinical models.

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

This study shows IL-2 enhances CD8+ T cell effector function but inhibits CXCR5+ TPEX cell formation and follicular infection control in chronic LCMV infection.

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice

This study shows that deleting Rbpj in hepatic progenitor cells reduces fibrosis and endothelial responses in DDC-fed mice by downregulating VCAM1 expression.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Prioritizing Maize Metabolic Gene Regulators through Multi-Omic Network Integration

This paper develops a framework to prioritize maize metabolic gene regulators by integrating multi-omic data, identifying over 3,000 TFs and predicting new regulators of hormone, developmental, and metabolic processes.

Unconventional IFNω-like genes dominate the type I IFN locus and the constitutive antiviral responses in bats

This study identifies unconventional IFNω-like genes as dominant in bat type I IFN loci and constitutive antiviral responses, revealing pan-bat immune system characteristics.

Uncovering Minimal Pathways in Melanoma Initiation

This study identifies LNM cells as a pre-malignant state in melanoma initiation, showing they pre-exist in normal skin, expand with Braf activation, and contribute to drug resistance.

MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants

This study identifies MaUGT79 as a gene regulating scopolin biosynthesis, which enhances drought tolerance in plants through ROS scavenging and transcriptional activation by MaMYB4.

Use of CRISPR interference for efficient and rapid gene inactivation in Fusobacterium nucleatum

This paper introduces a CRISPRi system for efficient gene inactivation in Fusobacterium nucleatum, demonstrating its effectiveness in both model and resistant strains.

Hormonal and transcriptomic analysis reveals the role of ABA and BR in breaking the barrier of inter-subgeneric hybridization in water lily (Nymphaea)

This study identifies ABA and BR as key regulators in overcoming inter-subgeneric hybridization barriers in water lily through transcriptomic and hormonal analyses.

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

Bacterial pathogens deliver water/solute-permeable channels as a virulence strategy

This study identifies AvrE/DspE-family effectors as water/solute-permeable channels that facilitate bacterial virulence by causing host cell swelling and death.

MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

SCFFBXW11 complex targets interleukin-17 receptor A for ubiquitin-proteasome-mediated degradation.

The paper identifies FBXW11 as a ubiquitin ligase that targets IL-17RA for proteasomal degradation through lysine 27-linked polyubiquitin chains.

Mutator transposon insertions within maize genes often provide a novel outward reading promoter

The study identifies Mu transposon insertions in maize genes that create outward-reading promoters, leading to complex transcripts and gene expression patterns similar to wild-type.

Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination

This study tracks memory T follicular helper cells and antibody response after three doses of CoronaVac vaccine over 300 days, showing increased neutralizing antibodies and cTFH cells, with correlation between cTFH and antibody titers.

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

Overexpression of the violaxanthin de-epoxidase confers faster NPQ and photosynthesis induction in rice

This study shows overexpressing VDE in rice speeds up NPQ and photosynthesis induction, reduces photoinhibition, and increases biomass by 11-16% in field conditions.

A HicA toxin-based counter-selection marker for allelic exchange mutations in Fusobacterium nucleatum

This paper introduces a HicA toxin-based counter-selection system for creating in-frame deletions in Fusobacterium nucleatum, demonstrating its effectiveness in generating markerless deletions.

A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides

This paper establishes a human iPSC-based in vitro assay to assess neurodevelopmental toxicity of pesticides by evaluating neural network formation and function.

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

This paper introduces a pseudovirus system for deep mutational scanning of SARS-CoV-2 spike protein mutations, showing how they affect antibody neutralization and infection.

Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes

The paper develops a proteomics-based classifier to predict lymph node metastasis in T1 colorectal cancer using protein expression patterns and machine learning.

Evolution of antibody immunity following Omicron BA.1 breakthrough infection

This study tracks antibody responses six months after Omicron BA.1 breakthrough infection and finds reduced neutralizing antibodies and memory B cells, with public clones dominating and predicting new sublineages.

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection

This study compares memory B cell responses after Delta and Omicron BA.1 breakthrough infections versus mRNA vaccine doses, finding that Delta infection boosts overall memory B cell potency and breadth, while Omicron infection only enhances strain-specific responses.

Conserved and variable responses of the HEAT SHOCK FACTOR transcription factor family in maize and Setaria viridis

The paper compares the HSF transcription factor family in maize and Setaria viridis, identifying conserved and variable heat stress responses and chromatin state differences.

Responses of Agricultural plants to Lithium pollution: Trends, Meta-Analysis, and Perspectives

This study conducts a meta-analysis of lithium's effects on plants, finding varied toxic responses based on exposure medium, source, and concentration.

A broad and potent neutralization epitope in SARS-related coronaviruses

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.