Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis
S. Beyaz, J. Roper, M. E. Xifaras, K. E. Bauer-Rowe, I. Ergin, L. Dohnalova, M. Biton, K. Shekar, H. Mou, O. Eskiocak, D. M. Ozata, C. Chung, K. Papciak, M. Almeqdadi, M. Fein, , O. H. Yilmaz
The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.
bioRxiv · Sep 5, 2020Cancer Biology