S. Beyaz

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer

This study shows CRISPR/Cas9 can induce exon skipping in β-catenin, creating gain-of-function mutations that drive distinct liver cancer subtypes in mice and are found in human HCC patients.

Excess dietary sugar impairs colonic epithelial regeneration in response to damage.

This study shows that high sugar diets impair colonic epithelial regeneration by altering metabolic pathways in intestinal stem cells.

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.