Author

A. Guna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. M. Voorhees· 4 shared A. J. Inglis· 2 shared G. Muthukumar· 2 shared J. S. Weissman· 2 shared M. L. Wang· 2 shared T. A. Stevens· 2 shared T. K. Esantsi· 2 shared T.-F. Chou· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCell Biology

R. M. Voorhees

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4 papers

Recent·Most cited

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins

K. R. Page, V. N. Nguyen, T. Pleiner, G. P. Tomaleri, M. L. Wang, A. Guna, T.-Y. Wang, T.-F. Chou, R. M. Voorhees

The paper studies the biogenesis of ER membrane proteins, identifying the EMC and BOS complex as key players and proposing a model for coordinated insertion.

bioRxiv · Nov 28, 2023Cell Biology

Triaging of -helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology

G. Muthukumar, T. A. Stevens, A. J. Inglis, T. K. Esantsi, R. A. Saunders, F. Schulte, R. M. Voorhees, A. Guna, J. S. Weissman

The paper identifies distinct chaperone machinery for targeting mitochondrial outer membrane -helical proteins based on their topology using CRISPRi screens and biochemical analysis.

bioRxiv · Aug 16, 2023Cell Biology

MTCH2 is a mitochondrial outer membrane protein insertase

A. Guna, T. A. Stevens, A. J. Inglis, J. M. Replogle, T. K. Esantsi, G. Muthukumar, K. C. L. Shaffer, M. L. Wang, A. N. Pogson, J. J. Jones, B. Lomenick, T.-F. Chou, J. S. Weissman, R. M. Voorhees

The paper identifies MTCH2 as an insertase required for mitochondrial TA protein insertion and shows its role in controlling TA localization and apoptosis sensitivity.

bioRxiv · Sep 15, 2022Cell Biology

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology

A. Stangherlin, D. C. S. Wong, S. Barbiero, J. L. Watson, A. Zeng, E. Seinkmane, S. P. Chew, A. D. Beale, E. A. Hayter, A. Guna, A. Inglis, E. Bartolami, S. Matile, N. Lequeux, T. Pons, , J. S. O'Neill

The paper shows that circadian protein rhythms are compensated by ion transport to maintain osmotic balance and cellular function in mammalian cells and cardiomyocytes.

bioRxiv · May 28, 2020Cell Biology