Author

E. Seinkmane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Zeng· 4 shared J. S. O'Neill· 4 shared A. D. Beale· 3 shared N. M. Rzechorzek· 3 shared A. Stangherlin· 2 shared D. C. S. Wong· 2 shared J. Day· 2 shared M. Putker· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

A. Zeng

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4 papers

Recent·Most cited

Circadian regulation of macromolecular complex turnover and proteome renewal

E. Seinkmane, A. L. Edmondson, S. Y. Peak-Chew, A. Zeng, N. M. Rzechorzek, N. R. James, J. A. West, J. Munns, D. C. Wong, A. D. Beale, J. S. O'Neill

This study investigates circadian regulation of protein turnover and proteome renewal, finding that synthesis and degradation rhythms consolidate proteome renewal while minimizing compositional changes.

bioRxiv · Sep 30, 2022Cell Biology

CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

M. Putker, D. Wong, E. Seinkmane, N. M. Rzechorzek, A. Zeng, N. P. Hoyle, J. E. Chesham, M. D. Edwards, K. A. Feeney, R. Fischer, N. Peschel, K.-F. Chen, C. P. Selby, A. Sancar, J. S. O'Neill

The paper shows that circadian rhythms persist in mice lacking CRY, suggesting that transcriptional feedback is not essential for timekeeping, but rather contributes to robustness.

The EMBO Journal · Jan 25, 2021Peer-reviewedCell Biology

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology

A. Stangherlin, D. C. S. Wong, S. Barbiero, J. L. Watson, A. Zeng, E. Seinkmane, S. P. Chew, A. D. Beale, E. A. Hayter, A. Guna, A. Inglis, E. Bartolami, S. Matile, N. Lequeux, T. Pons, , J. S. O'Neill

The paper shows that circadian protein rhythms are compensated by ion transport to maintain osmotic balance and cellular function in mammalian cells and cardiomyocytes.

bioRxiv · May 28, 2020Cell Biology

CRYPTOCHROME suppresses the circadian proteome and promotes protein homeostasis

D. C. S. Wong, E. Seinkmane, A. Stangherlin, A. Zeng, N. M. Rzechorzek, A. D. Beale, J. Day, M. Reed, S. Y. Peak-Chew, C. T. Styles, R. S. Edgar, M. Putker, J. S. O'Neill

This study compares the circadian proteome and phosphoproteome of wild-type and CRY-deficient fibroblast cells, finding increased circadian-regulated proteins and stress sensitivity in CRY-deficient cells.

bioRxiv · May 16, 2020Cell Biology