Triaging of -helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology
G. Muthukumar, T. A. Stevens, A. J. Inglis, T. K. Esantsi, R. A. Saunders, F. Schulte, R. M. Voorhees, A. Guna, J. S. Weissman
The paper identifies distinct chaperone machinery for targeting mitochondrial outer membrane -helical proteins based on their topology using CRISPRi screens and biochemical analysis.
bioRxiv · Aug 16, 2023Cell Biology